Predicting Heart Problems After a Heart Attack
Author Information
Author(s): Sposito Andrei, Coelho-Filho Otavio R, Andrade Joalbo M, Araújo Ana Laura R, Abdalla Dulcineia SP, Faria Eliana Cotta, van der Geest Rob J, Quinaglia Silva Jose C, Ramires Jose AF, Jerosch-Herold Michael, Kwong Raymond Y
Primary Institution: Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, Brazil
Hypothesis
The extent of the peri-infarct zone (PIZ) is associated with the severity of the systemic inflammatory response (SIR) after a myocardial infarction (MI).
Conclusion
The extent of the peri-infarct zone is a strong predictor of major adverse cardiovascular events and is closely linked to the systemic inflammatory response after a heart attack.
Supporting Evidence
- 25 major adverse cardiovascular events occurred during the follow-up period.
- CRP, IL-2, and TNF-α levels were strongly associated with the extent of the peri-infarct zone.
- Patients with a peri-infarct zone mass greater than the 50th percentile had reduced MACE-free survival.
Takeaway
Doctors can tell how likely someone is to have heart problems after a heart attack by looking at a specific area of heart tissue and how much inflammation is present.
Methodology
Patients were enrolled and assessed for systemic inflammatory response and peri-infarct zone using cardiac magnetic resonance imaging.
Participant Demographics
102 patients (24 females, mean age 55±10) with ST elevation myocardial infarction.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website