Characterizing Interactions Between Small Peptides and Dimethyl Sulfoxide Using Infrared Spectroscopy and Computational Methods
2024
Interactions Between Small Peptides and Dimethyl Sulfoxide
publication
Evidence: moderate
Author Information
Author(s): Panuszko Aneta, Pastwa Przemysław, Gajewski Jacek, Bruździak Piotr
Primary Institution: Department of Physical Chemistry, Gdańsk University of Technology
Hypothesis
How does dimethyl sulfoxide (DMSO) interact with small peptides in aqueous solutions?
Conclusion
DMSO influences peptide stability differently based on their structural characteristics.
Supporting Evidence
- DMSO does not form direct bonds with the peptides.
- DMSO modifies the surrounding water molecules, influencing peptide stability.
- The hydration shell of diglycine is strengthened by DMSO.
- NAGMA's hydration shell is less affected by DMSO due to structural similarities.
Takeaway
This study looks at how a chemical called DMSO interacts with two small proteins in water, showing that it affects them in different ways.
Methodology
The study used FTIR spectroscopy and DFT calculations to analyze the interactions between DMSO and the peptides.
Digital Object Identifier (DOI)
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