Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride
2011
Identifying Impurities in Verapamil Hydrochloride
publication
Evidence: high
Author Information
Author(s): Srinivasan Viswanathan, Sivaramakrishnan Hariharan, Karthikeyan Balakrishnan
Primary Institution: Piramal Healthcare Ltd
Hypothesis
The study aims to isolate and characterize unknown impurities in verapamil hydrochloride.
Conclusion
Two unknown impurities in verapamil hydrochloride were successfully isolated and characterized for the first time.
Supporting Evidence
- Two unknown impurities were detected in verapamil hydrochloride using HPLC.
- The impurities were characterized using NMR and mass spectrometry.
- This is the first report of these impurities in the literature.
Takeaway
The researchers found two new impurities in a heart medication called verapamil, which they studied to understand how they were formed.
Methodology
The impurities were isolated using preparative HPLC and characterized using mass spectrometry and NMR spectroscopy.
Digital Object Identifier (DOI)
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