Upregulation of HYAL1 Expression in Breast Cancer Promoted Tumor Cell Proliferation, Migration, Invasion and Angiogenesis
2011
HYAL1 and Breast Cancer
Sample size: 20
publication
Evidence: high
Author Information
Author(s): Tan Jin-Xiang, Wang Xiao-Yi, Su Xin-Liang, Li Hong-Yuan, Shi Yuan, Wang Liang, Ren Guo-Sheng
Primary Institution: First Affiliated Hospital of Chongqing Medical University
Hypothesis
Forcing HYAL1 expression in breast cancer cells promotes tumor progression.
Conclusion
Upregulation of HYAL1 in breast cancer cells enhances cell growth, migration, invasion, and angiogenesis.
Supporting Evidence
- HYAL1 expression was found to be overexpressed in breast cancer tissues.
- Breast cancer cells with higher HYAL1 expression showed significantly higher invasion ability.
- Forcing HYAL1 expression in breast cancer cells promoted tumor growth in a mouse model.
Takeaway
This study found that a protein called HYAL1 helps breast cancer cells grow and spread more easily.
Methodology
The study involved transfecting breast cancer cells with a plasmid to force HYAL1 expression and assessing various tumor-related behaviors in vitro and in vivo.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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