Structure Determination and Anti-Inflammatory Activity of Some Purine Complexes
1995
Study of Purine Complexes and Their Anti-Inflammatory Effects
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Satwinder S. Marwaha, Jasjest Kaur, Gurvinder S. Sodhi
Primary Institution: Punjabi University, Patiala, India
Hypothesis
The organomercury-purine complexes will exhibit anti-inflammatory activity.
Conclusion
The study found that certain organomercury-purine complexes showed varying degrees of anti-inflammatory activity.
Supporting Evidence
- Complex (II) showed 58% inhibition of edema.
- Complex (IV) showed 61% inhibition of edema.
- Complex (I) showed the least activity with 22% inhibition.
Takeaway
Scientists made new compounds using mercury and purines, and they found that some of these compounds can help reduce swelling in rats.
Methodology
The anti-inflammatory activity was evaluated using a carrageenan-induced paw edema model in rats.
Limitations
The concentration of test samples was different from that of the reference drug, indomethacin.
Participant Demographics
Charles Foster variety rats were used in the study.
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