Progesterone Receptors in Ovarian Cancer
Author Information
Author(s): Akahira J, Inoue T, Suzuki T, Ito K, Konno R, Sato S, Moriya T, Okamura K, Yajima A, Sasano H
Primary Institution: Tohoku University School of Medicine
Hypothesis
The study investigates the biological significance of progesterone receptor isoforms A and B in human epithelial ovarian carcinoma.
Conclusion
The study found that progesterone receptor B is an independent prognostic factor in ovarian carcinoma.
Supporting Evidence
- The labeling index for PRB was significantly higher than for PRA.
- PRB was identified as an independent prognostic factor.
- There was a significant correlation between ER-a and PRB labeling indices.
Takeaway
This study looked at two types of progesterone receptors in ovarian cancer and found that one type, PRB, can help predict how the cancer will behave.
Methodology
The study used immunohistochemistry on 107 cases and RT-PCR on 16 cases to analyze progesterone receptor isoforms.
Participant Demographics
Human epithelial ovarian carcinoma cases.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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