A facile synthesis and fungicidal activities of 2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-ones
2008
Synthesis and Fungicidal Activities of New Compounds
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Hu Yang-Gen, Zheng Ai-Hua, Ruan Xu-Zhi, Ding Ming-Wu
Primary Institution: Yunyang Medical College
Hypothesis
Can new thienopyrimidinones be synthesized and tested for fungicidal activity?
Conclusion
The study successfully synthesized new thienopyrimidinones that exhibited good to excellent fungicidal activities against several fungi.
Supporting Evidence
- The compounds showed good to excellent fungicidal activities against six kinds of fungi.
- Compounds 6b, 6d, 8a, 8c, and 8d showed 100% inhibition of Botrytis cinerea.
- The synthesis method used was efficient and yielded satisfactory results.
Takeaway
The researchers made new chemical compounds that can kill certain types of fungi, which could help in making better medicines.
Methodology
The compounds were synthesized using aza-Wittig reactions and their fungicidal activities were tested against six types of fungi.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website