Intermuscular Fat and Processing Speed in Older Adults
Author Information
Author(s): Xu Richard, Marron Megan, Yao Shanshan, Kim Seyoung, Shah Ravi, Murthy Venkatesh, Newman Anne, Rosano Caterina
Primary Institution: University of Pittsburgh
Hypothesis
Higher intermuscular fat is associated with worse processing speed in older adults.
Conclusion
The study suggests that certain metabolites may help explain the negative relationship between intermuscular fat and processing speed.
Supporting Evidence
- Higher intermuscular fat was associated with worse processing speed.
- 66 metabolites were associated with both intermuscular fat and processing speed.
- 24 metabolites significantly attenuated the association between intermuscular fat and processing speed.
Takeaway
Older people with more fat between their muscles tend to think slower, and some substances in their blood might explain why.
Methodology
The study assessed 613 plasma metabolites in participants using liquid chromatography-mass spectrometry and analyzed the data with linear regression and mediation analyses.
Participant Demographics
Average age 74.7 years, 50% men, 63% white.
Statistical Information
P-Value
<0.001
Confidence Interval
(-0.12, -0.03)
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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