Molecular Epidemiology of Fonsecaea Species
Author Information
Author(s): Najafzadeh Mohammad Javad, Sun Jiufeng, Vicente Vania A., Klaassen Corne H.W., Bonifaz Alexandro, van den Ende A.H.G. Gerrits, Menken Steph B.J., Sybren de Hoog G.
Primary Institution: Centraalbureau voor Schimmelcultures Fungal Biodiversity Centre, Utrecht, the Netherlands
Hypothesis
To assess population diversities among 81 strains of fungi in the genus Fonsecaea that had been identified down to species level.
Conclusion
The study found that Fonsecaea species show significant geographic structuring and clustering based on AFLP analysis.
Supporting Evidence
- Fonsecaea isolates clustered in 5 groups corresponding with F. pedrosoi, F. monophora, and F. nubica.
- F. pedrosoi was found nearly exclusively in Central and South America.
- F. monophora and F. nubica were distributed worldwide but showed substantial geographic structuring.
- Clinical cases outside endemic areas were likely spread by human migration.
Takeaway
This study looked at different types of fungi that can make people sick and found that they are spread out in different places around the world.
Methodology
The study used amplified fragment-length polymorphism (AFLP) technology and sequencing of specific genes to analyze the strains.
Limitations
The study did not have access to all strains for molecular verification, limiting the understanding of the epidemiology of the species.
Participant Demographics
The strains originated from clinical and environmental sources in the Western Hemisphere, Asia, Africa, and Europe.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website