Effects of Doxorubicin on Muscle Function
Author Information
Author(s): van Norren K, van Helvoort A, Argilés J M, van Tuijl S, Arts Karin, Gorselink M, Laviano A, Kegler D, Haagsman H P, van der Beek E M
Primary Institution: Danone Research – Centre for Specialised Nutrition
Hypothesis
Doxorubicin (DOX) directly impairs skeletal muscle function independent of oxidative stress.
Conclusion
Doxorubicin causes concentration- and time-dependent decreases in muscle performance, starting with impaired muscle relaxation.
Supporting Evidence
- Doxorubicin impaired muscle relaxation and contraction in a time- and concentration-dependent manner.
- Calcium responses in myotubes increased after doxorubicin exposure.
- Antioxidants did not reduce the calcium influx induced by doxorubicin.
Takeaway
Doxorubicin, a cancer drug, can make muscles weak and tired, which can make it hard for people to move around.
Methodology
The study assessed contractile characteristics of mouse skeletal muscle and measured calcium responses in myotubes after exposure to doxorubicin.
Participant Demographics
Male CD2F1 mice, 7–9 weeks old.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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