Effectiveness of Low vs Medium Dose Aspirin After Heart Surgery
Author Information
Author(s): Lim Eric, Cornelissen Jacqueline, Routledge Tom, Ali Ayyaz, Kirtland Stephen, Sharples Linda, Sheridan Kate, Bellm Sarah, Munday Helen, Large Stephen
Primary Institution: Papworth Hospital, Cambridge, UK
Hypothesis
Is low dose aspirin as effective as medium dose aspirin in inhibiting platelet aggregation after coronary surgery?
Conclusion
Low dose aspirin is effective and medium dose aspirin did not prove superior for inhibiting platelet aggregation after coronary surgery.
Supporting Evidence
- Both aspirin doses were effective in reducing platelet aggregation after surgery.
- The mean reduction in platelet aggregation was 37% for medium dose and 36% for low dose.
- No significant difference was found between the two doses in terms of effectiveness.
Takeaway
This study looked at how well low and medium doses of aspirin work after heart surgery. Both doses helped, but low dose aspirin was just as good as the medium dose.
Methodology
Patients were randomized to receive either 100 mg or 325 mg of aspirin daily for 5 days, and platelet aggregation was measured.
Potential Biases
Potential genetic differences in aspirin response may affect results.
Limitations
The study had a small sample size and some patients discontinued participation.
Participant Demographics
Patients undergoing elective primary coronary artery bypass surgery, with a mean age of 66 years.
Statistical Information
P-Value
0.19
Confidence Interval
95% CI -3 to 14
Statistical Significance
p = 0.19
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website