Gene transcription in LTβR-stimulated mouse embryonic fibroblasts
Author Information
Author(s): Lovas Agnes, Radke Dörte, Albrecht Daniela, Yilmaz Z Buket, Möller Ulrich, Habenicht Andreas JR, Weih Falk
Primary Institution: Leibniz Institute for Age Research, Fritz Lipmann Institute
Hypothesis
LTβR signaling, via RelA and/or RelB, may participate in physiological processes other than lymphorganogenesis.
Conclusion
The study provides insight into the transcriptional response of LTβR signaling and its regulation by the NF-κB family members RelA and RelB.
Supporting Evidence
- LTβR signaling influences immune responses and other biological processes.
- Both RelA and RelB are required for the regulation of many LTβR-responsive genes.
- LTβR activation inhibits expression of the adipogenic transcription factor pparg.
Takeaway
This study looks at how a specific receptor in cells helps control the activity of genes, which is important for understanding immune responses and other body functions.
Methodology
Microarray analysis was used to investigate the transcriptional response downstream of the LTβR in mouse embryonic fibroblasts.
Limitations
The study used an in vitro model system, which may not fully replicate in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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