Increased Prevalence of Albuminuria in HIV-Infected Adults with Diabetes
Author Information
Author(s): Kim Peter S., Woods Christian, Dutcher Lauren, Georgoff Patrick, Rosenberg Alice, Mican Jo Ann M., Kopp Jeffrey B., Smith Margo A., Hadigan Colleen
Primary Institution: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Hypothesis
What is the prevalence of albuminuria in HIV-infected patients with type 2 diabetes compared to those without diabetes?
Conclusion
HIV and diabetes have additive effects on albuminuria, which is also associated with increased exposure to abacavir and HIV viral load.
Supporting Evidence
- 34% of HIV-infected diabetics had albuminuria compared to 13% of HIV non-diabetics and 16% of diabetic controls.
- HIV status and diabetes were significant predictors of albuminuria after adjusting for other factors.
- Albumin/creatinine ratio correlated significantly with HIV viral load.
- HIV-infected subjects with albuminuria had greater cumulative exposure to abacavir.
Takeaway
People with both HIV and diabetes are more likely to have kidney problems than those with just one of these conditions.
Methodology
A cross-sectional study including 73 HIV-infected adults with type 2 diabetes, 82 HIV-infected non-diabetics, and 61 diabetic control subjects without HIV.
Potential Biases
Potential selection bias as participants concerned about diabetes or kidney function may have been more likely to participate.
Limitations
The study's cross-sectional design limits the ability to establish causality.
Participant Demographics
Participants included 73 HIV-infected adults with type 2 diabetes, 82 HIV-infected non-diabetics, and 61 diabetic controls without HIV.
Statistical Information
P-Value
p=0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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