Multiple Coronary Artery Thrombosis in a Patient with Gene Mutation
Author Information
Author(s): Alfonso Campanile, Sozzi Fabiola B., Danzi Gian Battista
Primary Institution: Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico
Hypothesis
Is hyperhomocysteinemia a significant risk factor for simultaneous thrombosis of multiple coronary arteries?
Conclusion
The case illustrates that elevated homocysteine levels due to a genetic mutation can lead to thrombosis in multiple coronary arteries.
Supporting Evidence
- Hyperhomocysteinemia is a known risk factor for coronary artery disease.
- The patient had a homozygotic mutation of the 5,10-methylenetetrahydrofolate reductase gene.
- After treatment, the patient had no cardiac events during a nine-month follow-up.
Takeaway
A man with high homocysteine levels due to a gene mutation had blood clots in two heart arteries, but he is doing fine after treatment.
Methodology
The patient underwent emergency coronary angiography and received thrombus aspiration and stenting.
Limitations
The study is based on a single case, limiting generalizability.
Participant Demographics
A 42-year-old male with a history of smoking and family coronary artery disease.
Digital Object Identifier (DOI)
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