SLC37A1 and SLC37A2 Are Antiporters
Author Information
Author(s): Pan Chi-Jiunn Chen, Shih-Yin Jun, Hyun Sik Lin, Su Ru Mansfield, Brian C. Chou, Janice Y.
Primary Institution: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health
Hypothesis
Are SLC37A1 and SLC37A2 functional sugar-phosphate antiporters?
Conclusion
SLC37A1 and SLC37A2 are functional sugar-phosphate antiporters but do not couple with G6Pase-α, suggesting they do not play a role in blood glucose homeostasis.
Supporting Evidence
- SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport G6P.
- Neither SLC37A1 nor SLC37A2 is sensitive to chlorogenic acid, a known inhibitor of G6P transport.
- Only G6PT/SLC37A4 matches the characteristics of the physiological ER G6P transporter.
Takeaway
This study found that two proteins, SLC37A1 and SLC37A2, can move sugar and phosphate in and out of cells, but they don't help control blood sugar levels.
Methodology
The study used reconstituted proteoliposomes to examine the antiporter activity of SLC37 family members and their ability to couple with G6Pase-α.
Limitations
The study does not explore the functional roles of SLC37A1 and SLC37A2 outside of blood glucose homeostasis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website