Testing the Implementation Framework for Behavioral and Lifestyle Interventions in Alzheimer’s Disease
Author Information
Author(s): Salisbury Dereck, Lin Vankee, Yu Fang
Primary Institution: University of Minnesota
Hypothesis
The study evaluates the implementation outcomes of the MOBILIZE framework in multi-site behavioral intervention trials for Alzheimer's disease.
Conclusion
MOBILIZE helped the ACT Trial achieve high intervention adherence and safety, which is crucial for early-stage and multi-site trials in Alzheimer's disease.
Supporting Evidence
- The sample had an average age of 73.8 years and a Montreal Cognitive Assessment score of 23.4.
- Intervention adherence was 77.4% on average.
- There were 9 study-related adverse events reported.
Takeaway
The study looked at how well a new plan worked to help people with Alzheimer's stick to their exercise and brain training programs.
Methodology
The study systematically evaluated implementation outcomes of a multi-site aerobic exercise and cognitive training trial using the MOBILIZE framework.
Limitations
Screening-to-enrollment and intervention adherence varied across sites, influenced by COVID-19.
Participant Demographics
Participants were 73.8 years old on average, 48.0% female, and 91.8% white.
Digital Object Identifier (DOI)
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