Prioritizing Genes for Parkinson's Disease Risk
Author Information
Author(s): Lange Lara M., Cerquera-Cleves Catalina, Schipper Marijn, Panagiotaropoulou Georgia, Braun Alice, Kraft Julia, Awasthi Swapnil, Bell Nathaniel, Posthuma Danielle, Ripke Stephan, Blauwendraat Cornelis, Heilbron Karl
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
We aimed to prioritize genes underlying Parkinson's disease genome-wide association study signals.
Conclusion
We identified and prioritized 46 genes linked to Parkinson's disease that may aid in drug development.
Supporting Evidence
- We identified 120 independent associations with strong statistical significance.
- We prioritized genes with potential links to drug repurposing for Parkinson's disease.
- Some prioritized genes are already targeted in ongoing clinical trials.
Takeaway
The study found important genes related to Parkinson's disease that could help create new medicines.
Methodology
We used the polygenic priority score method to analyze data from the largest published PD GWAS.
Participant Demographics
East Asian and European ancestries
Statistical Information
P-Value
p<5×10−8
Statistical Significance
p<5×10−8
Digital Object Identifier (DOI)
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