Gastric Changes After Long-Term Use of Vonoprazan: A Case Report
Author Information
Author(s): Suda Hiroko, Eto Sachi, Sakurai Koichi
Primary Institution: Hattori Clinic, Kumamoto, Japan
Hypothesis
What are the effects of long-term Vonoprazan use on gastric mucosa?
Conclusion
Long-term use of Vonoprazan can lead to significant gastric mucosal changes and severe rebound acid hypersecretion after discontinuation.
Supporting Evidence
- The patient developed significant gastric epithelial changes after 6 years of Vonoprazan use.
- After switching to H2 blockers, the patient experienced rebound acid hypersecretion.
- Histological analysis showed parietal cell and G-cell hyperplasia.
Takeaway
Taking a medicine called Vonoprazan for a long time can change your stomach and make it hurt more when you stop taking it.
Methodology
A case report of a 76-year-old man who used Vonoprazan for 6 years, followed by observations of gastric and duodenal changes after medication switch.
Limitations
The findings are based on a single case report, limiting generalizability.
Participant Demographics
76-year-old male with a history of hypertension and previous proton pump inhibitor use.
Digital Object Identifier (DOI)
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