Injectable Gel for Sustained Delivery of Altrenogest
Author Information
Author(s): Li Dongbo, Abbas Awn, Li Nanxin, Li Chao, Ai Xiaoyang, Chen Lian, Dai Dongmei, Shu Gang, Lin Juchun, Zhang Wei, Peng Guangneng, Li Haohuan, Xu Funeng, Fu Hualin, Călina Ion Cosmin, Raza Muhammad Asim
Primary Institution: Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Hypothesis
Can a phospholipid-based injectable gel improve the delivery and efficacy of altrenogest in swine production?
Conclusion
The altrenogest gel demonstrated effective sustained release and improved pharmacokinetic properties compared to the oral solution.
Supporting Evidence
- The altrenogest gel had a viscosity of 100 cP before phase transition and over 1,000,000 cP after phase transition.
- In vitro, altrenogest can be continuously released from gel for over two weeks.
- The AUC (0–∞) of the altrenogest gel was almost double that of the altrenogest solution.
- The MRT (0–∞) was 40.92 ± 7.21 h and the t1/2 of the altrenogest gel was 80.03 ± 20.79 h.
- The injectable altrenogest gel showed a proper sustained-release behavior in vitro and in vivo.
Takeaway
Scientists created a special gel that can slowly release a hormone for pigs, making it easier to manage their breeding without giving them medicine every day.
Methodology
The study involved preparing a phospholipid-based gel, testing its viscosity, release profile, and pharmacokinetics in rats.
Limitations
Pharmacokinetic and pharmacodynamic studies have not been conducted on sows, and irritation and safety evaluations of the injectable gel are needed.
Participant Demographics
Female Sprague Dawley rats (190–210 g) were used for the pharmacokinetic study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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