Mortality from Acinetobacter baumannii Infections in Critically Ill Patients
Author Information
Author(s): Matthew E. Falagas, Ioannis A. Bliziotis, Ilias I. Siempos
Primary Institution: Alfa Institute of Biomedical Sciences (AIBS)
Hypothesis
Does infection with Acinetobacter baumannii increase morbidity and mortality independently of other factors?
Conclusion
Infection with or acquisition of A. baumannii is associated with increased mortality in critically ill patients.
Supporting Evidence
- The mortality attributable to A. baumannii infection ranged from 7.8% to 23% in hospital settings.
- ICU mortality for patients with A. baumannii infection ranged from 10% to 43%.
- Statistically significant higher mortality was reported for patients with A. baumannii acquisition compared to controls.
Takeaway
Getting sick from a germ called Acinetobacter baumannii can make really sick people in the hospital even sicker and can lead to more deaths.
Methodology
A systematic review of matched case-control and cohort studies comparing mortality of patients with and without A. baumannii infection.
Potential Biases
Some studies did not account for other factors influencing mortality.
Limitations
Methodological heterogeneity and lack of matching for disease severity in some studies.
Participant Demographics
Critically ill patients in intensive care units.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 34–52
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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