GRIM-1, a Novel Growth Suppressor, Inhibits rRNA Maturation by Suppressing Small Nucleolar RNAs
2011
GRIM-1: A Growth Suppressor That Affects rRNA Maturation
publication
Evidence: moderate
Author Information
Author(s): Nallar Shreeram C., Lin Limei, Srivastava Varsha, Gade Padmaja, Hofmann Edward R., Ahmed Hafiz, Reddy Sekhar P., Kalvakolanu Dhananjaya V.
Primary Institution: University of Maryland School of Medicine
Hypothesis
How does GRIM-1 influence rRNA maturation and cell growth?
Conclusion
GRIM-1 acts as a growth suppressor by inhibiting rRNA maturation through the suppression of small nucleolar RNAs.
Supporting Evidence
- GRIM-1 depletion conferred a growth advantage in the presence of retinoic acid and interferon.
- GRIM-1 expression is lost in many human primary prostate tumors.
- GRIM-1 isoforms interact with essential proteins required for snoRNA biogenesis.
Takeaway
GRIM-1 is a protein that helps control how cells grow by affecting the production of a key part of the cell's machinery, called rRNA.
Methodology
The study used RNA interference to deplete GRIM-1 and measured the effects on cell growth and rRNA processing.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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