Matrix Metalloproteinases in Basal Cell Carcinoma
Author Information
Author(s): Varani J, Hattori Y, Chi Y, Schmidt T, Perone P, Zeigler M E, Fader D J, Johnson T M
Primary Institution: The University of Michigan Medical School
Hypothesis
The study investigates the presence and activity of matrix metalloproteinases (MMPs) and their inhibitors in basal cell carcinoma compared to normal skin.
Conclusion
The same profile of MMPs and their inhibitors associated with stromal invasion in organ culture is also expressed in basal cell carcinomas of the skin.
Supporting Evidence
- MMP-1 was responsible for most of the functional collagenolytic activity.
- Gelatinolytic activity was reflected by both MMP-2 and MMP-9.
- MMP inhibitor activity was present and reflected TIMP-1 but not TIMP-2.
- Normal skin showed low to undetectable levels of collagenolytic and gelatinolytic activities.
Takeaway
The study looked at skin cancer samples and found that certain enzymes are more active in cancer than in normal skin.
Methodology
Tissue from 54 basal cell carcinomas was analyzed for matrix metalloproteinases and their inhibitors using functional and immunochemical procedures.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website