The Role of Macrophage Scavenger Receptor A in Meningococcal Septicaemia
Author Information
Author(s): Plüddemann Annette, Hoe J. Claire, Makepeace Katherine, Moxon E. Richard, Gordon Siamon
Primary Institution: Sir William Dunn School of Pathology, University of Oxford
Hypothesis
Does the Macrophage Scavenger Receptor A (SR-A) play a protective role in meningococcal septicaemia?
Conclusion
The study found that SR-A is protective against meningococcal septicaemia, as mice lacking SR-A showed higher levels of bacteraemia and reduced survival.
Supporting Evidence
- SR-A−/− mice showed a 33% reduction in survival compared to wild-type mice.
- SR-A−/− animals had higher levels of bacteraemia and increased IL-6 levels.
- Mutant bacteria lacking SR-A ligands caused less severe symptoms and higher survival rates.
Takeaway
Mice with a special receptor called SR-A are better at fighting off a type of bacteria that can cause serious illness. Without this receptor, the mice got sick faster and had a harder time surviving.
Methodology
The study used a murine model to compare the health and survival of wild-type and SR-A−/− mice infected with Neisseria meningitidis.
Limitations
The study's mouse model does not fully represent natural meningococcal disease pathogenesis.
Participant Demographics
C57BL/6J wild-type and corresponding SR-A−/− knock-out mice.
Statistical Information
P-Value
0.0305
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website