Viral Infection: A Barrier to Transplantation Tolerance
Author Information
Author(s): David M. Miller, Thomas B. Thornley, Dale L. Greiner, Aldo A. Rossini
Primary Institution: University of Massachusetts Medical School
Hypothesis
Can viral infections prevent the induction of transplantation tolerance?
Conclusion
Viral infections can significantly impair the induction and maintenance of transplantation tolerance, leading to increased risk of allograft rejection.
Supporting Evidence
- Viral infections can prevent the induction of tolerance by costimulation blockade.
- LCMV infection can lead to significant morbidity and mortality in transplantation settings.
- Costimulation blockade therapies have shown promise in animal models but face challenges in the presence of viral infections.
Takeaway
When people get organ transplants, viruses can make it harder for their bodies to accept the new organ without needing medicine to suppress their immune system.
Methodology
The review discusses various experimental approaches and findings related to transplantation tolerance and the effects of viral infections.
Limitations
The review primarily focuses on animal models, which may not fully represent human responses.
Digital Object Identifier (DOI)
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