Glycyrrhizin as an antiviral agent against Hepatitis C Virus
Author Information
Author(s): Ashfaq Usman A, Masoud Muhammad S, Nawaz Zafar, Riazuddin Sheikh
Primary Institution: University of the Punjab, Lahore, Pakistan
Hypothesis
The study investigates the antiviral effect of Glycyrrhizin against Hepatitis C Virus (HCV).
Conclusion
Glycyrrhizin inhibits HCV viral particles and core gene expression in a dose-dependent manner and shows a synergistic effect with interferon.
Supporting Evidence
- Glycyrrhizin resulted in a 50% reduction of HCV at a concentration of 14 ± 2 μg.
- At a concentration of 40 μg, viral inhibition by Glycyrrhizin reached up to 89%.
- Glycyrrhizin exhibited a synergistic effect with interferon, resulting in a 95% reduction in viral titer.
Takeaway
Glycyrrhizin, a compound from licorice root, can help fight the Hepatitis C virus and works even better when combined with another treatment called interferon.
Methodology
HCV infected liver cells were treated with Glycyrrhizin, and HCV titer was measured using Quantitative real-time RT-PCR.
Limitations
The study primarily focuses on in vitro results, which may not fully represent in vivo efficacy.
Participant Demographics
Patients with chronic Hepatitis C infection from Lahore, Pakistan.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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