Molecular evolution of the LNX gene family
2011
Evolution of the LNX Gene Family
publication
Evidence: moderate
Author Information
Author(s): Flynn Michael, Saha Orthis, Young Paul
Primary Institution: University College Cork
Hypothesis
What are the phylogenetic origins and evolutionary relationships of the LNX gene family?
Conclusion
The LNX gene family originated in early metazoans, with specific functions acquired in vertebrates.
Supporting Evidence
- The LNX gene family has been maintained in vertebrates, suggesting essential functions.
- Ancestral LNX genes were lost in some invertebrate lineages, indicating non-essential roles.
- Phylogenetic analysis traced the LNX gene family back to early metazoans.
Takeaway
Scientists studied a family of proteins called LNX to understand how they evolved over time and found that they have important roles in vertebrates.
Methodology
The study involved phylogenetic analysis of LNX gene sequences from various metazoan species.
Limitations
The in vivo functions of LNX proteins remain largely unclear due to low expression levels in cell lines.
Digital Object Identifier (DOI)
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