Calcitonin Reduces Bone Loss in Mice with Calcitonin Deficiency
Author Information
Author(s): Kauther Max D, Bachmann Hagen S, Neuerburg Laura, Broecker-Preuss Martina, Hilken Gero, Grabellus Florian, Koehler Gabriele, Knoch Marius, Wedemeyer Christian
Primary Institution: University Duisburg-Essen
Hypothesis
Calcitonin substitution might inhibit particle-induced osteolysis and that Calca deficient mice might develop a greater extent of osteolysis compared to the WT.
Conclusion
Calcitonin substitution reduces particle-induced osteolysis in Calca deficient mice.
Supporting Evidence
- Bone resorption was significantly increased in Calca -/- mice compared with their corresponding WT.
- The eroded surface in Calca -/- mice with particle implantation was reduced by 20.6% after CT substitution.
- Osteoclast numbers were significantly increased in Calca -/- mice after particle implantation.
Takeaway
This study found that giving calcitonin to mice that lack it helps reduce bone loss caused by particles that can loosen implants.
Methodology
The study used a murine calvarial osteolysis model with different groups of wild-type and Calca deficient mice, some receiving calcitonin injections.
Potential Biases
The lack of a control group for vehicle or placebo effects may introduce bias.
Limitations
The study used a flat bone model and different animal facilities, which may introduce variability.
Participant Demographics
The study involved male C57BL/6J wild-type and Calca deficient mice, aged twelve weeks.
Statistical Information
P-Value
p < 0.0000002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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