Correlations Between Systemic Parameters and Coronary Artery Disease
Author Information
Author(s): Nunes José Pedro L., Silva João Carlos
Primary Institution: Faculdade de Medicina da Universidade do Porto, Porto, Portugal
Hypothesis
What are the correlations between systemic parameters and the magnitude of coronary artery disease as assessed by angiography?
Conclusion
Plasma glucose was found to be correlated to coronary artery atherosclerosis lesions.
Supporting Evidence
- Significant correlation values versus CADB were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048), and fasting plasma glucose (r 0.33, p<0.001).
- Linear regression analysis showed a significant value for glucose (p 0.018) and for sex (0.008).
- The composite parameter glucose/magnesium product also yielded a significant correlation with CADB (r 0.37, p<0.001).
Takeaway
This study looked at how different body measurements relate to heart disease, and found that higher blood sugar levels are linked to more serious heart problems.
Methodology
An observational study was conducted on 116 patients with coronary heart disease, analyzing correlations between coronary artery disease burden and various systemic parameters.
Potential Biases
Patients were frequently under the influence of lipid-lowering and anti-diabetic drugs, which may affect the results.
Limitations
The study had a relatively small sample size and potential selection bias, as patients were observed as outpatients.
Participant Demographics
116 patients (80 male, 36 female), aged 62.0±10.5 years, mostly Caucasian.
Statistical Information
P-Value
p<0.001 for fasting plasma glucose
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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