Alternatives to Ciprofloxacin for Enteric Fever in the UK
Author Information
Author(s): Threlfall E. John, de Pinna Elizabeth, Day Martin, Lawrence Joanne, Jones Jane
Primary Institution: Health Protection Agency, London, UK
Hypothesis
What are the alternative drug therapies available for treating enteric fever due to resistance to ciprofloxacin?
Conclusion
The efficacy of ciprofloxacin for treating enteric fever in the UK is compromised, but alternatives like ceftriaxone and azithromycin are viable.
Supporting Evidence
- Resistance to ciprofloxacin in S. Typhi increased from 35% in 2001 to 70% in 2006.
- Resistance to ciprofloxacin in S. Paratyphi A rose to 73% in 2006.
- 21 treatment failures with ciprofloxacin have been documented since 2005.
Takeaway
Doctors need to find other medicines to treat typhoid fever because some germs are not getting better with the usual medicine.
Methodology
The study analyzed resistance patterns of Salmonella enterica serovars Typhi and Paratyphi A from 2001 to 2006.
Limitations
The study faced challenges in accurately documenting foreign travel history due to underreporting.
Participant Demographics
Patients with typhoid and paratyphoid fever, with a significant proportion having traveled abroad.
Digital Object Identifier (DOI)
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