Potentially Inappropriate Medications in Diabetic Nephropathy Patients
Author Information
Author(s): Muacevic Alexander, Adler John R, Nisa Mehr, Naseralallah Lina, Altarawneh Lina, Ally Roaa, Danjuma Mohammed
Primary Institution: Hamad Medical Corporation
Hypothesis
What is the prevalence of potentially inappropriate medications (PIMs) among patients with diabetic nephropathy?
Conclusion
The study found a high prevalence of potentially inappropriate medications among patients with diabetic nephropathy, particularly in older individuals and those with lower kidney function.
Supporting Evidence
- 28.8% of patients were prescribed at least one potentially inappropriate medication.
- Older age, lower eGFR, and polypharmacy were significant predictors of PIM prescriptions.
- NSAIDs were the most commonly prescribed potentially inappropriate medications.
Takeaway
Many patients with diabetic nephropathy are taking medications that could be harmful to their kidneys, especially older patients and those taking multiple drugs.
Methodology
A cross-sectional study analyzing clinical and electronic data from patients with diabetic nephropathy at Hamad Medical Corporation.
Potential Biases
Exclusion of patients with acute kidney injury or those on dialysis may introduce selection bias.
Limitations
The study's cross-sectional design limits causality establishment and may not be generalizable as it was conducted at a single hospital.
Participant Demographics
Mean age of 64.2 years, majority male (56.4%), with common comorbidities including hypertension (82.1%) and cardiovascular disease (47.3%).
Statistical Information
P-Value
<0.05
Confidence Interval
95% CI 1.21-1.92
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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