Impact of polysialylated CD56 on natural killer cell cytotoxicity
2007
Impact of polysialylated CD56 on natural killer cell cytotoxicity
publication
Evidence: moderate
Author Information
Author(s): Jeannette M Moebius, Darius Widera, Juergen Schmitz, Christian Kaltschmidt, Christoph Piechaczek
Primary Institution: Miltenyi Biotec GmbH
Hypothesis
Is polysialylated CD56 on NK cells masking Siglec-7?
Conclusion
PSA-NCAM is not involved in masking Siglec-7.
Supporting Evidence
- PSA-NCAM was found to be expressed on functional NK cells.
- Removal of PSA did not affect NK cell cytotoxicity.
- Clostridium perfringens neuraminidase treatment significantly reduced NK cell killing efficiency.
Takeaway
The study found that a specific molecule on NK cells doesn't hide another important receptor, which helps them kill infected cells.
Methodology
FACS analysis and killing assays were used to examine PSA expression and its impact on NK cell function.
Statistical Information
P-Value
p = 0.0025
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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