Determinants of Vertebral Endplate Changes and Disc Degeneration in Middle-Aged Male Workers
Author Information
Author(s): Kuisma Mari, Karppinen Jaro, Haapea Marianne, Niinimäki Jaakko, Ojala Risto, Heliövaara Markku, Korpelainen Raija, Kaikkonen Kaisu, Taimela Simo, Natri Antero, Tervonen Osmo
Primary Institution: Oulu University Hospital
Hypothesis
Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same?
Conclusion
Weight-related factors are important for Modic changes, while whole-body vibration is a significant determinant of severe disc degeneration.
Supporting Evidence
- 56% of participants had Modic changes.
- Age was significantly associated with all degenerative changes.
- BMI was associated with type II changes at L5-S1.
- Whole-body vibration exposure was linked to severe disc degeneration.
Takeaway
This study looked at what causes changes in the spine and found that being heavier can lead to certain changes, while vibration from work can cause more serious problems.
Methodology
228 middle-aged male workers underwent MRI and completed a questionnaire about their occupational history and lifestyle factors.
Potential Biases
Recall bias may affect the accuracy of self-reported lifestyle factors.
Limitations
The study's cross-sectional nature limits the ability to establish temporal relationships between determinants and outcomes.
Participant Demographics
228 Caucasian males with a mean age of 47 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI reported for various odds ratios
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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