PPARGC1A Gene and Its Impact on Sports Performance
Author Information
Author(s): David Varillas-Delgado, Luisa Politano
Primary Institution: Universidad Francisco de Vitoria
Hypothesis
The PPARGC1A gene, particularly the rs8192678 polymorphism, influences sports performance and metabolic health.
Conclusion
The rs8192678 polymorphism significantly affects athletic performance, with the G allele providing advantages in endurance sports and the A allele presenting mixed implications for strength and metabolic health.
Supporting Evidence
- The G allele is linked to better endurance performance due to enhanced mitochondrial efficiency.
- The A allele is associated with reduced aerobic capacity and increased risk of metabolic diseases.
- Genetic profiling may help in personalizing training and health interventions.
Takeaway
Some people have a gene that helps them do better in sports. If you have one version of the gene, you might be better at running long distances, while another version might help with strength activities.
Methodology
A comprehensive literature search was conducted using databases such as PubMed, Scopus, Science Direct, and Web of Science, following PRISMA guidelines.
Potential Biases
Differences in population genetics and training methodologies may introduce bias.
Limitations
Variability in study designs and potential publication bias were acknowledged.
Digital Object Identifier (DOI)
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