Tissue Inhibitor of Metalloproteinases-4: The road less traveled
2008
Tissue Inhibitor of Metalloproteinases-4: The Road Less Traveled
publication
Evidence: moderate
Author Information
Author(s): Melendez-Zajgla Jorge, Pozo Luis Del, Ceballos Gisela, Maldonado Vilma
Primary Institution: Instituto Nacional de Medicina Genomica
Conclusion
TIMP-4 has a complex role in cancer, with its expression levels varying across different types of tumors and stages of cancer progression.
Supporting Evidence
- TIMP-4 expression is found in various tissues including heart, kidney, and brain.
- Elevated levels of TIMP-4 have been associated with several types of tumors.
- Down-regulation of TIMP-4 has been observed in pancreatic and clear cell renal tumors.
- TIMP-4 may act as a natural anti-invasive protein by inhibiting certain metalloproteinases.
Takeaway
TIMP-4 is a protein that helps control how cells grow and die, and it can affect cancer in different ways depending on the type of cancer.
Limitations
The study highlights the need for more research to clarify TIMP-4's role in cancer due to conflicting results in different studies.
Digital Object Identifier (DOI)
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