Drug-induced alterations in tumour perfusion yield increases in tumour cell radiosensitivity
2001
Drug Changes Make Tumors More Sensitive to Radiation
publication
Author Information
Author(s): Bennewith K L, Durand R E
Primary Institution: British Columbia Cancer Research Centre
Hypothesis
Can drug-induced alterations in tumor perfusion increase tumor cell radiosensitivity?
Conclusion
Increasing tumor perfusion can enhance the radiosensitivity of certain tumor cells, particularly those that are transiently hypoxic.
Supporting Evidence
- Increased tumor perfusion led to greater radiosensitivity in WiDr tumors compared to SiHa tumors.
- Redistribution of blood flow within WiDr tumors was observed independently of net tumor perfusion changes.
- Fluorescence-activated cell sorting showed increased radiosensitivity in WiDr tumor cells at intermediate oxygen levels.
Takeaway
Giving certain drugs can help tumors get more oxygen, which makes them easier to treat with radiation.
Methodology
Tumor perfusion was manipulated using diltiazem and pentoxifylline, and the effects on radiosensitivity were measured in different tumor types.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website