Response to Chemotherapy in Inoperable Lung Adenocarcinoma
Author Information
Author(s): J.B. Sørensen, J.H. Badsberg, H.H. Hansen
Primary Institution: Finsen Institute/Rigshospitalet, University of Copenhagen
Hypothesis
What are the prognostic factors for response to chemotherapy in patients with inoperable adenocarcinoma of the lung?
Conclusion
The study found that response to chemotherapy was not a significant predictor of future survival in patients with inoperable adenocarcinoma of the lung.
Supporting Evidence
- Only 20-40% of patients achieve an objective response to chemotherapy.
- Patients with measurable disease had a higher likelihood of responding than those with evaluable disease.
- Response status did not significantly impact survival when compared to other pretreatment variables.
Takeaway
Doctors wanted to see if chemotherapy helps people with a type of lung cancer that can't be operated on. They found that just because someone responds to the treatment doesn't mean they'll live longer.
Methodology
The study analyzed 259 patients with inoperable adenocarcinoma of the lung treated in a chemotherapy trial, evaluating response rates and survival based on various pretreatment variables.
Potential Biases
Potential observer variation in response assessment could affect results.
Limitations
The study's findings may not apply to all histological types of lung cancer, and the majority of responses were partial.
Participant Demographics
Patients included were consecutive cases with inoperable adenocarcinoma, aged up to 70 years, with a Karnofsky performance status of 50% or better.
Statistical Information
P-Value
P=0.02
Confidence Interval
0.48-1.73
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