Impact of Fungicides on Neural Crest Cell Migration
Author Information
Author(s): Magel Viktoria, Blum Jonathan, Dolde Xenia, Leisner Heidrun, Grillberger Karin, Khalidi Hiba, Gardner Iain, Ecker Gerhard F., Pallocca Giorgia, Dreser Nadine, Leist Marcel
Primary Institution: University of Konstanz
Hypothesis
Can strobilurin fungicides inhibit neural crest cell migration and contribute to developmental toxicity?
Conclusion
The study found that strobilurin fungicides, particularly picoxystrobin, significantly inhibit neural crest cell migration, which may lead to developmental toxicity.
Supporting Evidence
- Strobilurin fungicides were identified as specific inhibitors of mitochondrial respiratory chain complex III.
- Picoxystrobin was selected for further study due to its significant impact on neural crest cell migration.
- Mechanistic studies showed that picoxystrobin inhibited oxygen consumption in neural crest cells.
- Biokinetic modeling predicted that brain concentrations of picoxystrobin could reach levels associated with toxicity.
- A margin of exposure of ≥ 80 was calculated between the lowest in vitro point of departure and the highest predicted tissue concentration.
Takeaway
Some chemicals, like certain fungicides, can stop important cells in our body from moving where they need to go, which can cause problems as we grow.
Methodology
The study used a cell-based assay to screen 115 compounds for their effects on neural crest cell migration and confirmed hits through various assays.
Limitations
The study's findings may not fully translate to in vivo conditions due to the complexity of biological systems.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website