Differential effects of cisplatin in proximal and distal renal tubule epithelial cell lines
1999
Effects of Cisplatin on Kidney Cells
publication
Evidence: moderate
Author Information
Author(s): Kröning R, Katz D, Lichtenstein A K, Nagami G T
Primary Institution: West Los Angeles VA Medical Center and UCLA School of Medicine
Hypothesis
Different portions of the nephron exhibit varying sensitivities to cisplatin.
Conclusion
Cells from different parts of the nephron show different sensitivities to cisplatin and varying transport characteristics.
Supporting Evidence
- S1 cells were the most sensitive to cisplatin, followed by S3 and distal convoluted tubule cells.
- Cisplatin triggered apoptosis in all three cell lines.
- BCL-XL expression was significantly lower in S1 cells compared to S3 and DCT cells.
Takeaway
This study found that kidney cells react differently to a cancer drug called cisplatin, which can affect how well the drug works.
Methodology
The study examined the cytotoxicity and uptake of cisplatin in cell lines derived from different segments of the nephron.
Digital Object Identifier (DOI)
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