Hyaluronan production increases the malignant properties of mesothelioma cells
2001
Hyaluronan Increases Malignancy in Mesothelioma Cells
publication
Evidence: moderate
Author Information
Author(s): Li Y, Heldin P
Primary Institution: Uppsala University
Hypothesis
Does hyaluronan production affect the malignant properties of mesothelioma cells?
Conclusion
Hyaluronan production enhances the aggressive characteristics of mesothelioma cells.
Supporting Evidence
- Hyaluronan overproduction changed mesothelioma cells from an epitheloid to a fibroblastic phenotype.
- The size of pericellular matrices correlated with the amount of synthesized hyaluronan.
- HAS2-transfected cells showed a 2-fold increase in CD44 receptor expression.
- Increased locomotion was observed in HAS2-transfected cells compared to mock-transfected cells.
- Malignant properties of mesothelioma cell clones correlated with their hyaluronan production.
Takeaway
When mesothelioma cells make more hyaluronan, they become more aggressive and spread more easily.
Methodology
The study involved expressing murine hyaluronan synthase 2 in a non-hyaluronan producing mesothelioma cell line and assessing changes in cell properties.
Digital Object Identifier (DOI)
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