Fine Needle Aspiration Cytology of Bone Tumours
Author Information
Author(s): Nnodu Obiageli E, Giwa SO, Eyesan Samuel U, Abdulkareem Fatima B
Primary Institution: National Orthopaedic Hospital Lagos, Nigeria
Hypothesis
Can sufficient material be obtained to arrive at reliable tissue diagnosis in patients with clinical and radiological evidence of bone tumours?
Conclusion
FNAC can be useful in the pre-operative assessment of bone tumours especially where other diagnostic modalities are unavailable.
Supporting Evidence
- Material sufficient for diagnosis was obtained in 90 out of 96 patients.
- Cytological diagnosis of benign lesions was made in 40 patients and malignant in 47.
- The accuracy of specific cytological diagnosis was 87.8%.
- Sensitivity was 95% and specificity was 94% for distinguishing benign from malignant lesions.
Takeaway
Doctors used a small needle to take samples from patients with bone tumours to see if they could tell if the tumours were cancerous or not, and it worked well for most patients.
Methodology
Patients underwent fine needle aspirations after clinical and radiographic examinations, and the samples were analyzed microscopically.
Potential Biases
Limited experience and reliance on morphologic criteria may introduce bias.
Limitations
Only 42.7% of patients had subsequent surgical biopsy and histology for correlation.
Participant Demographics
57 males, 39 females, mean age 31.52 years, age range 4–76 years.
Digital Object Identifier (DOI)
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