Novel therapeutic approach: organic arsenical (melarsoprol) alone or with all-trans -retinoic acid markedly inhibit growth of human breast and prostate cancer cells in vitro and in vivo
2000
New Treatment for Breast and Prostate Cancer
publication
Evidence: moderate
Author Information
Author(s): Koshiuka K, Elstner E, Williamson E, Said J W, Tada Y, Koeffler H P
Primary Institution: UCLA School of Medicine, Cedars-Sinai Medical Center
Hypothesis
Can melarsoprol alone or with all-trans-retinoic acid effectively inhibit the growth of breast and prostate cancer cells?
Conclusion
Melarsoprol, alone or combined with all-trans-retinoic acid, significantly inhibits the growth of breast and prostate cancer cells.
Supporting Evidence
- Melarsoprol was effective in inhibiting the growth of MCF-7, PC-3, and DU145 cancer cells.
- The combination of Melarsoprol and all-trans-retinoic acid showed enhanced effects against cancer cells.
- Treatment with Melarsoprol and all-trans-retinoic acid reduced tumor size and weight in mice.
Takeaway
This study found that a drug called melarsoprol can help stop breast and prostate cancer from growing, especially when used with another drug.
Methodology
The study tested the effects of melarsoprol and all-trans-retinoic acid on cancer cells in lab tests and in mice.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website