PRFdb: A Database for Ribosomal Frameshift Signals
Author Information
Author(s): Belew Ashton T, Hepler Nicholas L, Jacobs Jonathan L, Dinman Jonathan D
Primary Institution: University of Maryland, College Park, MD, USA
Hypothesis
The PRFdb aims to provide a comprehensive resource for identifying programmed -1 ribosomal frameshift signals in eukaryotic genes.
Conclusion
The PRFdb enables researchers to determine potential -1 PRF signals in genes they are studying and serves as a resource for cross-referencing with other databases.
Supporting Evidence
- The PRFdb provides a user-friendly interface for researchers.
- It compiles data from multiple genomes to identify -1 PRF signals.
- The database allows for searching and filtering of sequences based on specific criteria.
Takeaway
PRFdb is like a library that helps scientists find special signals in genes that can change how proteins are made.
Methodology
Sequences are imported and filtered through algorithms to identify potential -1 PRF signals based on specific structural features.
Limitations
The database may not include all potential recoding signals and relies on computational predictions.
Digital Object Identifier (DOI)
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