Structural multiplicity in a solvated hydrate of the antiretroviral protease inhibitor Lopinavir
2024
Structure of Lopinavir Crystal
publication
Evidence: high
Author Information
Author(s): Mokoto Tebogo M. L., Lemmerer Andreas, Sayed Yasien, Smith Mark G.
Primary Institution: University of the Witwatersrand, Johannesburg, Gauteng, South Africa
Hypothesis
The study aims to understand the structure of Lopinavir crystals using various solvents during crystallization.
Conclusion
The study successfully characterized a unique multi-component solvated crystal structure of Lopinavir.
Supporting Evidence
- Lopinavir is a potent protease inhibitor used for HIV treatment.
- The crystal structure contains 18 molecules in a unique arrangement.
- The study utilized single-crystal X-ray diffraction for characterization.
Takeaway
The researchers made a special crystal using Lopinavir, a medicine for HIV, and found it has a unique structure with many molecules stuck together.
Methodology
The crystal was prepared using evaporative methods and characterized by single-crystal X-ray diffraction.
Digital Object Identifier (DOI)
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