Connection Between Sulphur Metabolism and Cellulase Gene Expression in Fungi
Author Information
Author(s): Gremel Gabriela, Dorrer Marcel, Schmoll Monika
Primary Institution: Institute of Chemical Engineering, Vienna University of Technology
Hypothesis
Sulphur signaling/metabolism and regulation could be interconnected processes in Hypocrea jecorina.
Conclusion
The study indicates that the significance of the sulphate/methionine-related signal with respect to cellulase gene expression is dependent on the light status.
Supporting Evidence
- LIMPET, a putative E3 ubiquitin ligase, binds to the cellulase activating element and is regulated by sulphur availability.
- Transcription of lim1 is up-regulated under sulphur limitation and responds to cellulase-inducing conditions.
- Sulphate uptake is essential for growth in light on cellulose, indicating a unique regulatory mechanism in H. jecorina.
Takeaway
This study found that how fungi use sulphur affects their ability to break down cellulose, and this process changes depending on whether it's light or dark.
Methodology
The study used various cultivation conditions to analyze the transcriptional regulation of cellulase genes and the role of sulphur sources.
Digital Object Identifier (DOI)
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