Midkine and Early Stage Colorectal Cancer
Author Information
Author(s): Ye C, Qi M, Fan Q-W, Ito K, Akiyama S, Kasai Y, Matsuyama M, Muramatsu T, Kadomatsu K
Primary Institution: Fujita Health University School of Medicine
Hypothesis
Does midkine contribute to the early stage of carcinogenesis in colorectal cancer?
Conclusion
Midkine expression is significantly elevated in colorectal adenomas and carcinomas compared to normal tissues.
Supporting Evidence
- Midkine expression was significantly more elevated in adenomas than in normal tissues.
- A difference in MK expression was also observed between carcinomas and corresponding normal tissues.
- MK immunostaining was positive in adenomas with moderate- and severe-grade dysplasia and in carcinomas.
Takeaway
Midkine is a protein that seems to be more present in early stages of colorectal cancer, which might help us understand how this cancer develops.
Methodology
The study examined MK mRNA levels in 20 adenomas and 28 carcinomas using Northern blotting.
Participant Demographics
The study included 20 adenomas with moderate- and severe-grade dysplasia and 28 carcinomas.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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