Muscle Mass Loss and Physical Function in Adults with Diabetes
Author Information
Author(s): Taiane de Azevedo Cardoso, Shun Matsuura, Kornanong Yuenyongchaiwat, Aki Naruse, Yuka Yamada, Takeshi Miyamoto
Primary Institution: Kumamoto University Hospital
Hypothesis
This study aims to assess the prevalence of skeletal muscle loss in young to middle-aged adults with diabetes and examine the relationship between skeletal muscle loss and physical function.
Conclusion
Young to middle-aged adults with diabetes experience significant skeletal muscle mass loss and reduced physical function, particularly men.
Supporting Evidence
- 18.2% of men and 7.7% of women with diabetes showed skeletal muscle mass loss.
- Men with diabetes had significantly lower muscle strength and physical function compared to healthy controls.
- Logistic regression analysis indicated that BMI and peripheral neuropathy were significantly associated with muscle mass loss.
Takeaway
People with diabetes can lose muscle strength and have trouble moving around, even if they are not old.
Methodology
This was a cross-sectional, observational study involving patients with type 2 diabetes who were admitted for rehabilitation.
Potential Biases
The study was limited by its single-center design and retrospective nature, which may introduce selection bias.
Limitations
The study had a small sample size, especially in the female control group, and was retrospective, leading to missing data.
Participant Demographics
Participants were young to middle-aged adults with type 2 diabetes, aged under 65, with a mix of men and women.
Statistical Information
P-Value
P<0.001
Confidence Interval
95% CI 1.07-1.23
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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