XIAP as a New Prognostic Biomarker in Breast Cancer
Author Information
Author(s): Zhang Yutao, Zhu Jianhua, Tang Yun, Li Feng, Zhou Hongyuan, Peng Bofang, Zhou Chifeng, Fu Rong
Primary Institution: The First People's Hospital of Zigong, Zigong, China
Hypothesis
The study aimed to investigate the relationship between XIAP/Smac expression and prognosis in breast invasive ductal carcinoma (IDC).
Conclusion
XIAP positive nuclear labeling is a new independent prognostic biomarker of breast invasive ductal carcinoma.
Supporting Evidence
- XIAP was found to be expressed in 84.3% of IDC samples, while Smac was only expressed in 33.3%.
- XIAP positive nuclear labeling was significantly correlated with shortened overall survival.
- Survival analysis indicated that XIAP-N was an independent prognostic factor.
Takeaway
This study found that a protein called XIAP in the nucleus of breast cancer cells can help predict how well patients will do.
Methodology
Immunohistochemistry and TUNEL assays were used to analyze XIAP and Smac expression in breast cancer samples.
Limitations
The study had a limited number of fresh IDC specimens for analysis.
Participant Demographics
All patients were female with breast invasive ductal carcinoma who underwent modified radical mastectomy.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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