BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency Granulopoiesis
2023
BCG Vaccine and Its Effects on Immune Training
publication
Evidence: moderate
Author Information
Author(s): Andualem Henok, Hollams Elysia, Kollmann Tobias R., Amenyogbe Nelly
Primary Institution: Department of Medical Laboratory Science, College of Health Science, Debre Tabor University, Ethiopia
Hypothesis
Emergency granulopoiesis and trained immunity are a continuum of the same effect cascade mediated by the BCG vaccine.
Conclusion
BCG vaccination may optimize pathogen-agnostic benefits by considering the recipient's age and the route of administration.
Supporting Evidence
- BCG vaccination at birth reduces all-cause mortality in high-mortality settings.
- Trained immunity can protect against a wide spectrum of pathogens.
- Emergency granulopoiesis is a rapid response to severe infection.
- Neutrophils are among the innate immune cells that can be trained.
- Route of BCG administration affects the induction of trained immunity.
Takeaway
The BCG vaccine helps our immune system remember how to fight off different germs, not just the one it was made for.
Limitations
The precise molecular mechanisms by which BCG induces trained immunity and emergency granulopoiesis are not fully understood.
Digital Object Identifier (DOI)
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