Therapeutic Effect of DA-7867 in Mice with Nocardia brasiliensis Infection
Author Information
Author(s): Vera-Cabrera Lucio, Daw-Garza Alejandra, Said-Fernández Salvador, Lozano-Garza Hector Gerardo, de Torres Noemi Waksman, Rocha Norma Cavazos, Ocampo-Candiani Jorge, Choi Sung-Hak, Welsh Oliverio
Primary Institution: Servicio de Dermatología, Hospital Universitario “José E. González”, Monterrey, Nuevo León, México
Hypothesis
The study evaluates the in vivo effect of DA-7867, an experimental oxazolidinone, on the development of mycetomas caused by Nocardia brasiliensis in BALB/c mice.
Conclusion
DA-7867 is effective in reducing lesions caused by Nocardia brasiliensis in mice, suggesting its potential for human application.
Supporting Evidence
- DA-7867 was able to reduce the production of lesions at 25 mg/kg.
- The drug was effective whether administered subcutaneously or in drinking water.
- DA-7867 maintained plasma concentrations above the MIC for over 10 hours.
Takeaway
Researchers tested a new medicine called DA-7867 on mice to see if it could help treat a skin infection caused by a germ. It worked well and might help people too!
Methodology
BALB/c mice were infected with Nocardia brasiliensis and treated with DA-7867 or linezolid, with lesion development assessed over six weeks.
Limitations
The study was conducted in an animal model, and results may not directly translate to human patients.
Participant Demographics
BALB/c mice, eight-to-twelve weeks old, female.
Statistical Information
P-Value
0.002
Statistical Significance
p=0.002
Digital Object Identifier (DOI)
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