Selective interactions between epithelial tumour cells and bone marrow mesenchymal stem cells
2000
Interactions Between Breast Cancer Cells and Bone Marrow Stem Cells
publication
Author Information
Author(s): Hombauer H, Minguell J J
Primary Institution: Unidad de Biología Celular, INTA, Universidad de Chile
Hypothesis
How do epithelial metastatic breast cancer cells interact with bone marrow mesenchymal stem cells?
Conclusion
Breast cancer cells grow differently when interacting with bone marrow stem cells compared to fibroblasts.
Supporting Evidence
- Breast cancer cells showed high adhesion rates to both mesenchymal stem cells and fibroblasts.
- Breast cancer cells grew in clusters on fibroblasts but dispersed when interacting with mesenchymal stem cells.
- Low levels of adhesion molecules were expressed by breast cancer cells when grown on mesenchymal stem cells.
Takeaway
Breast cancer cells can stick to and grow on special cells from bone marrow, but they behave differently than when they grow on other types of cells.
Methodology
The study compared the growth and adhesion of breast cancer cells in co-culture with bone marrow mesenchymal stem cells and fibroblasts.
Digital Object Identifier (DOI)
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